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The effects depend on the amount used and how the body reacts during research testing

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Here, we show that CagriSema blunts metabolic adaptation in rats

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In a Phase 2b study in people with type 2 diabetes and obesity over 54 weeks, treatment with cotadutide at doses of 100-300 g daily improved some non-invasive markers of NAFLD such as transaminase levels, the FIB-4 index, fatty liver disease fibrosis score (NFS) and fatty liver index (FLI) but fatty liver disease was not assessed directly with liver biopsy

These shifts hint at how GLP-1s might also support sobriety and addiction, offering hope to those pursuing broader wellness goals